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It interacts with various enzymes and target genes to regulate responses to changes in oxygen concentration, promote vascularization, and support tissue repair

For example, drug candidates that act as electrophiles and react with Keap1 thiol groups could act on other electrophile-sensitive pathways, such as histone deacetylase enzymes

However, the exact details of this regulatory composition remain a melody to be fully composed

Subsequently, downstream transcription factors such as X-box binding protein 1 (XBP1) and activating transcription factor-6 (ATF6) are activated (293), initiating the transcription of genes involved in ERS-related responses