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It also interacts with the NRF2 pathway: studies show that the MOTS-cNRF2 interaction can increase the expression of protective mitochondrial genes, enhancing the cells ability to cope with stress and damage

The term meso is derived from the mesoderm or middle layer of the skin (approx

Of note, in a more recent study on cerebrovascular disease in older adults, higher plasma choline concentrations were associated with a favourable cardiometabolic risk-factor profile, like elevated HDL-concentration 72