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Disclosures This work is funded by the Doris Duke Charitable Foundation Background Smoking is well-known to be associated with cancers of several internal organs, including the lung, bladder, pancreas, larynx and cervix Knowledge of numerous carcinogens in cigarette smoke and their link to cancers of internal organs eventually led to studies on smoking and skin cancer (NMSC and melanoma) Background Inverse association is somewhat puzzling, especially in light of well-known risks of smoking High probability of a confounder Inconsistent controlling for skin type and history of UV exposure, or history of blistering sunburns among previous studies Hypothesis When carefully adjusting for sun exposure, skin type, and history of blistering sunburns, cigarette smoking will either: Show no association with risk for melanoma OR 2

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