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TABLE 1 Overview of the small molecule inhibitors targeting NNMT

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Final Thoughts GHK-Cu offers a science-backed, regenerative approach to skin and hair research, with over 50 years of published work, roughly 4,000 documented gene interactions, and clinical trials showing measurable wrinkle reduction, increased collagen density, and improved hair-cell activity in models

Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13