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It should be noted that (i) aralar activity is required initially for reversal of cytosolic NAD + /NADH changes occurring during the one oxidative process occurring during pyruvate formation, but subsequently not in astrocytes until the oxidation of glutamate, probably allowing rapid glutamate synthesis, and (ii) all reactions are stoichiometrically accounted for (A ) From Pardo et al

- In cases of chronic disease: half the dose at intervals of 1 - 2 weeks or less

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