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Acts as a macrophage DAMP molecule like MSU crystals to promote hyperuricemia and its complications ( via NLRP3 inflammasomes in macrophages ( UA activates phagocytosis by macrophages MSU crystals promote phagocytosis by macrophages

Neuron 2012

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MEVs are a specific type of extracellular vesicles (EVs), which is a collective term that describes particles naturally released from the cell that are delimited by a lipid bilayer and cannot replicate, i.e., do not contain a functional nucleus (28)