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However, our included studies intervening with a dosage higher than 2000mg/d seemed to show more benefit to patients [9,10], while one subgroup [9] with 1500mg/d showed less reduction in VAS (p value not provided)

These transporters all adopt the major facilitator superfamily (MFS) fold and are capable of translocating a range of different molecules across the plasma membrane, including endogenous substrates, clinically relevant drugs and xenobiotics 12