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Description

546 ME Association

doi: 10.1056/NEJMoa2312323 52

The molecular basis of X-linked immunodeficiency disease

CD8 + T cells release interferon- (IFN-), which downregulates the expression of SLC3A2 and SLC7A11, the two subunits of the System Xc , inhibiting cystine uptake by tumor cells and promoting ferroptosis (Wang et al