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Phylogenetic analysis revealed support for four main evolutionary groups, namely GPX1/GPX2 (100%), GPX3/GPX5/GPX6 (84%), GPX7/GPX8 (99%), and PHGPX (i.e., Vertebrata GPX4) (77%

Although Wnt-mediated immune evasion has been associated with distinct immune checkpoint and markers of exhaustion expression (including PD-L1, CTLA-4, LAG3, CD86, ICOS, ICOSLG and TNFSF9) (184, 185), a high density of CD163+ myeloid cells and anti-PD1 treatment resistance has observed in overactivated Wnt-PARP signaling (186)