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Symptoms of vitamin B12 deficiency include: Anemia Intestinal disorders and weight loss Fatigue, weakness, lightheadedness Memory loss or confusion Depression or dementia Rapid heartbeat and respiration Mouth or tongue soreness or bleeding Excessive bruising Injections are the most effective means of administration of vitamin B12 since they do not depend on the body's ability to absorb the substance through the gastrointestinal tract

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In the structure of E-RTC, two nsp13 zinc-binding domains form extensive interactions with two nsp8 N-terminal helices

Numerous studies indicate that mercuric ions in- teract with glutathione (GSH) and other (SH) groups in the presence of hydrogen peroxide, leading to the gen- eration of reactive oxygen species (ROS)