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Microbiota dysbiosis also contributes to the pathogenesis of visceral pain in irritable bowel disease which affects between 5 and 10% of the general population worldwide and involves multiple processes including immune, humoral and neuroendocrine (HPA axis) factors, autonomic (nervus vagus) and enteric nervous systems, spinal afferents nerves, 5-HT, SCFAs, tryptophan-related metabolites, gut hormones, and neurometabolites (dopamine, GABA, noradrenaline) (Moloney et al., 2015, 2016

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