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Successively, it was shown that TIGAR, a protein involved in the inhibition of the glycolytic pathway, could limit starvation-induced ATG by means of its ability to indirectly suppress ROS production (Bensaad et al., 2009)

Furthermore, NCOA4 enhances intracellular iron levels during redox reactions by facilitating the absorption of iron from ferritin, thereby promoting ferroptosis

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However, treatment with Mn@mHSA or P-Mn@mHSA attenuated the secretion of TNF- and IL-6, with cells treated with P-Mn/TI@mHSA exhibiting the lowest concentrations of these cytokines due to synergistic effects