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Compared to healthy states, their subgingival microbiota displays dysbiosis, characterised by increased pathogenic bacteria and reduced beneficial bacteria

3,984,569, supra, which is hereby incorporated by reference

When managing patients taking opioid analgesics, particularly those who have been treated for an extended period of time, and/or with high doses for chronic pain, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper

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