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The downregulation of macrophages activity through the overexpression of CD47 is already known as a mechanism for cancer cells to escape the immune system

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Such circumstances have directed healthcare systems toward being more reactive than proactive, prioritizing treatment of illnesses over prevention, ultimately resulting in massive expenses to medically intervene (114116)

This effect may be attributed to the blood glucose-lowering effect of metformin, which maintains a glucose-deprived environment unfavorable for cancer cell growth, thus increasing the efficacy of chemotherapy