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How GHK-Cu Works (Mechanism of Action) GHK-Cu functions primarily as: A copper delivery molecule A modulator of gene expression A regulator of extracellular matrix remodelling Copper is an essential cofactor for enzymes involved in: Collagen cross-linking Angiogenesis Antioxidant defense Tissue remodelling GHK-Cu appears to: Increase synthesis of collagen types I and III Stimulate dermal fibroblast activity Modulate matrix metalloproteinases (MMPs) Reduce pro inflammatory signalling in wound models Its effects are local and tissue specific rather than systemic and hormonal

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Editorial Advisory Board Member, Harvard Health Publishing If you haven't gotten the shingles vaccine (Shingrix) because you've heard it can make you feel sick, you might want to reconsider

Other proposed contributors discussed in the literature include modulation of the dopaminergic and serotonergic systems, growth hormone receptor expression in fibroblasts, and interaction with the nitric oxide system at the level of vasomotor regulation (Sikiric et al., 2018)