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For example, chrysin and kaempferol can suppress the Akt/mTOR pathway by significantly activating the AMPK signaling pathway (Lu et al., 2017

Once you puncture the rubber stopper, you've introduced potential contamination

Front Biosci (Schol Ed) 3:12161231 Gu Y, Zheng G, Xu M, Li Y, Chen X, Zhu W, Tong Y, Chung SK et al (2012) Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and bloodbrain barrier permeability in focal cerebral ischemia and reperfusion injury