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The transcription factor T-brachyury and adherens junction protein N-cadherin are highly expressed NP cells during early development as compared to mature NP cells or NP cells in a degenerated disc environment (Minogue et al., 2010)

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A more comprehensive evaluation of the same cohort using spatial transcriptomics revealed more detailed vascular and immunological features of microvessels in the brain, including serum protein extravasation, platelet accumulation and coagulation system activation 22