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Schliep KC, Mumford SL, Peterson CM, Chen Z, Johnstone EB, Sharp HT, et al

Catalpol administration to mice also inhibited HPA axis hyperactivity (reflected in lower levels of corticosterone, ACTH, and CRH), central inflammation, and oxidative damage via regulation of the NF-B and Nrf2 pathways, producing antidepressant effects in mice injected with corticosterone [60]