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The activation of PPAR/ can promote mitochondrial biogenesis and enhance mitochondrial generation and function by upregulating the expression of PGC-1

56-OR: A long-acting glucose-dependent insulinotropic polypeptide receptor agonist shows weight loss without nausea or vomiting

Investig New Drugs

The identification of dysregulated incretin secretion and action in both obesity and diabetes led to the revolutionary discovery of incretin-based drugs, such as glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) and dual glucose-dependent insulinotropic peptide (GIP)/GLP-1 RAs [24,25,26,27,28]