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Colorectal cancer statistics, 2020

During ischemia, the lack of oxygen and nutrients leads to a depletion of ATP and the accumulation of metabolic waste products, creating a highly stressful environment for cardiac cells

A high NAD/NADH ratio such as the oxidized state favors reactions like PHGDH and sustains flux through glycolysis into anabolic routes [15], whereas a reducing environment might slow such biosynthesis and divert pyruvate to lactate instead