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PMID 17434786

2010 Dec;30(12):1417-8

Berryman DE, Glad CAM, List EO, Johannsson G

Complementarily, IGF-1R preferentially activates IRS-2 [120] as it was found that IRS-2 contains a KLRB domain that functions to block the tyrosine kinase domain in the cytoplasmic region of the IR, and that such does not happen in the IGF-1R