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51 Obstructive sleep apnoea In a one-year study of adults with moderate to severe obstructive sleep apnoea and obesity about half of whom were treated with positive airway pressure at baseline tirzepatide 10 or 15 mg once weekly resulted in a clinically meaningful reduction in the apnoeahypopnoea index compared with placebo

Consistent with the distribution of Firmicutes in the cecal samples, the relative abundance of Ileibacterium was highest in the WD controls (average relative abundance 68%), second highest in the LD controls (average relative abundance 51%), and lowest in the vehicle- and 5A-1MQ-treated mice switched from WD to LD (average relative abundances of 40% and 41%, respectively)

Long-Term Management of Overdosage Continuous care involves observing for any enduring consequences, like nerve impairment or heart related concerns and applying supportive treatments when needed

doi: 10.1007/s10565-014-9285-2