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In particular, the E4 allele mediated decline in MCA and LCAs within the cerebrovasculature at 50 weeks may indicate that cerebrovascular mitochondrial FAO flux is impaired earlier in E4 relative to other alleles, especially in female E4s who fail to increase acylcarnitines with age, and at older ages in the same animal model have been shown to fail to increase AA as an alternative energy source compared to male E4s (Shang et al., 2020)