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CARDIOVASCULAR SYSTEM Today there is evidence of the protective effect of mild to moderately elevated levels of bilirubin against diseases related to oxidative stress

G6PD inhibition has been shown to impair cellular migration through ROS-dependent inhibition of protein phosphatases involved in cytoskeletal rearrangement, suggesting that chronic ROS accumulation in G6PD-d may inhibit B1 migration necessary for IgM OSE production 87,144,145 (Fig