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This triggers downstream signaling pathways (e.g., NF-B and MAPK), driving the massive release of pro-inflammatory cytokines, including IL-1, IL-6, and TNF- (167170)

(2014) demonstrated the role of a 14-residue long extra sequence, exclusively present in Bacillus GGTs at the C-terminus of the large subunit, in autoprocessing, structural stability, and catalysis of BlGGT