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196 The use of spironolactone and oral contraceptives has been shown to be more effective than either alone for PCOS-related unwanted hair growth, and is often recommended for treating moderate-to-severe unwanted hair growth, or mild unwanted hair growth that is not sufficiently resolved after six months of treatment with oral contraceptives

Grx2 contains the CSYC active site, allowing it to accept electrons from TrxR [28] and to form the dimeric Fe 2 S 2 -bridged holo-complex [21,29]

Furthermore, co-immunoprecipitation revealed that alcohol-induced pBTK interacted with NLRP3, stabilizing the inflammasome complex

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