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For instance, enhanced hepatic perfusion resulting from aerobic activity may facilitate the targeted delivery and absorption of active phytochemicals, while exercise-induced ROS generation may synergize with polyphenol-mediated Nrf2 activation to upregulate endogenous antioxidant systems

In another study with a collagen-induced arthritis mouse model, the IL-6 level was lower in the moxibustion-treated group than the untreated group (122)

Therefore, NAD+ might be a transformer that affects the endogenous effects of NLPR3, and appropriate NAD+ supplementation could reduce myocardial inflammation using activated SIRTs and NRF2 signaling (Table 1)

Nutrients 15 (19), 4176