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Additionally, in the skin of NRF2-deficient psoriasis-like mice, the STAT3 and NF-B pathways were activated, and K16 expression increased (Fig

In addition, tryptophan depletion and kynurenine accumulation induce the formation of immunosuppressive regulatory T cells (Tregs), leading to tumor growth (Heng et al., 2016)

The most common adverse reactions that have been reported with topical azelaic acid formulations are burning, itching, stinging, dryness, and erythema which are temporary and mild (Kirsch et al., 2019