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In 2006, Santel et al

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Decision tree for translational use of urinary OPN and NGAL in a drug development program Following the determination that OPN and NGAL can add value to conventional biomarkers for monitoring kidney tubular degeneration/necrosis in a prospective rat GLP study, sponsors are encouraged to discuss proposals for use of human urinary OPN and NGAL to enable the safe conduct of clinical studies with the appropriate regulatory review body