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Reportedly, the blood concentration of pirfenidone 5-carboxy-pirfenidone metabolite excreted through the kidneys significantly increases in patients with severe renal impairment (area under the curve of mild, moderate, and severe renal impairment was 49.3, 100, and 168 mghr/L, respectively

The compound functions as a selective ghrelin receptor (GHS-R1a) agonist, demonstrating high binding affinity and activation specificity compared to other growth hormone releasing peptides

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Written informed consents were obtained from the donors and the recipients or their families