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This conclusion has been confirmed by showing that cytosolic expression of GSH synthase rescues the seedling lethal gsh2 mutant (Pasternak et al., 2008)

These free radicals are highly toxic and an exquisite fine control of how much and where in the cell they are generated is needed

S-adenosylmethionine (SAM), a product of one carbon metabolism, serves as the universal methyl donor for methyltransferase enzymes, which catalyze transfer of the sulfonium methyl group of SAM to nucleophilic acceptors such as the -amino group of lysine residues on proteins 13 , the 5-position of cytosine in DNA 46 and RNA 7,8 , or the ethanolamine head group of phosphatidylethanolamine in lipids 9,10

Nuclear factor-Kb The nuclear factor kappa B (NF-kB) signaling pathway serves a crucial role in regulating the transcriptional responses of physiological processes including cell division, cell survival, differentiation, immunity, and inflammation [83]