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Once the EVs accumulate in glioblastoma tissues where glutathione levels are extremely high, the disulfide bonds are reductively cleaved, resulting in efficient drug release at the target site [182]

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"Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice" Proc Natl Acad Sci U S A 111(35): E3669-3678

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Recently, researchers have also demonstrated the use of longer wavelengths, in particular beyond 1 \(\upmu \)m, for increasing the signal-to-noise ratio of the measurements 20

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