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The intestinal microbiota affect GABA which transmit signals to the brain trough enteric nerve s (142)

Searches used combinations of controlled vocabulary (e.g., MeSH where available) and free-text terms capturing (i) PF and related descriptors and (ii) DPN and closely related phenotypes (including painful diabetic neuropathy and diabetic polyneuropathy), supplemented by mechanism- and endpoint-related concepts (e.g., oxidative stress, neuroinflammation, Schwann cell/myelination, axonal integrity, microvascular dysfunction, and drug delivery)

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At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562)