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The treatment reduced neuronal expression of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d)/neuronal nitric oxide (nNOS) and consequently improved survival of the motor neurons in the hypoglossal nucleus and dorsal motor nucleus of the vagal nerve in the brainstem [30] (Table 1)

These effects are achieved by modulating the threshold of T-cell activation via intracellular signalling through PD-1 expressed on T-cells, which is inhibitory to T-cell Receptor signalling (Okazaki and Honjo 2007)

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