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Further investigation revealed minimal impact of Tripterygium wilfordii on NLRP3/caspase-1 levels in MPTP-treated Nrf2-KO mice, suggesting that the extract may exert its anti-PD effects by activating Nrf2 to subsequently inhibit the NLRP3 inflammasome (Figure 4)

The regulation of peripheral metabolism by gut-derived hormones

SD, RD, and ZS are employees of Lonza, while KJ is a consultant to Lonza

In contrast, the endogenous ubiquitin-proteasome system (UPS) represents a natural regulatory mechanism that maintains proteostatic balance by selectively tagging and degrading damaged or unwanted proteins [17,18,19,20]