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The durability of metabolic benefits after washout, the consequences of chronic pan-ERR activation in heart and kidney, and the potential for tolerance or compensatory network changes require longer studies

Siegert, R

The discrepancies between both studies could be due, at least in part, to the different anatomic injection site employed, since, as indicated above, thigh injections have been rated more painful than injections in the abdomen [25, 26]