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*Correspondence: C (Linda) MC van Campen, [email protected] This article was submitted to Pharmaceutical Medicine and Outcomes Research, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Hes1 and Hey1, known as direct downstream targets of Notch, belong to an extensive family of basic helix-loop-helix (bHLH) proteins and play a critical role in the regulation of cell cycle and apoptosis in various cancers [52, 53]

Glycerin: It acts on the skin by fortifying the epidermal barrier, shielding it from irritants, pollutants and environmental aggressors

Oxidative stress is a common pathological feature of chronic diseases associated with prolonged ID [30,31,32]