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This limitation reflects a broader gap in the field: most randomized controlled trials and systematic reviews focus on major depressive disorder or depressive symptoms in heterogeneous populations, without separate analyses for distinct presentations like vascular depression, treatment-associated depressive states, or mood disturbances in the context of specific medical conditions

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Increased iron load and exacerbated lipid peroxidation are key features of ferroptosis, aligning closely with the molecular biological changes observed in the brains of PD patients (de Farias et al., 2016