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Injection may be done systemically, such as in the abdomen or thigh, or locally near the symptomatic soft-tissue region

Paradoxically, just after toxicity onset, there may be brief hypertension or fast heart rate, followed by severe hypotension

Moreover, for further details on which vitamin B12 active ingredient to choose, see our article: Vitamin B12 Forms Vitamin B12 Overdose Since vitamin B12 is considered harmless and hardly any negative side effects of an overdose of the vitamin are known, some experts recommend playing it safe when it comes to B12