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While considerable insight has been gained into the in vitro biochemical activity of Pol particularly in the context of exogenous DNA damageits physiological role in vivo remains poorly understood

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In the aberrant crypt focus (ACF) rat model induced with 1.2 Dimethylhydrazine (DMH) at a 20 mg/kg dose, the experimental treatment group (DMH + Zingiberene at a 300 mg/kg concentration) showed decreased amount of AC in the distal region compared with the positive induction control group (81)