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Adverse Reactions/Side Effects The following serious and otherwise important adverse drug reactions are discussed in greater detail in other sections of labeling: Disabling and Potentially Irreversible Serious Adverse Reactions [see Warnings and Precautions (5.1)] Tendinitis and Tendon Rupture [see Warnings and Precautions (5.2)] Peripheral Neuropathy [see Warnings and Precautions (5.3)] Central Nervous System Effects [see Warnings and Precautions (5.4)] Exacerbation of Myasthenia Gravis [see Warnings and Precautions (5.5)] Other Serious and Sometimes Fatal Adverse Reactions [see Warnings and Precautions (5.6)] Hypersensitivity Reactions [see Warnings and Precautions (5.7)] Hepatotoxicity [see Warnings and Precautions (5.8)] Risk of Aortic Aneurysm and Dissection [see Warnings and Precautions (5.9)] Serious Adverse Reactions with Concomitant Theophylline [see Warnings and Precautions (5.10)] Clostridioides difficile-Associated Diarrhea [see Warnings and Precautions (5.11)] Prolongation of the QT Interval [see Warnings and Precautions (5.12)] Musculoskeletal Disorders in Pediatric Patients [see Warnings and Precautions (5.13)] Photosensitivity/Phototoxicity [see Warnings and Precautions (5.14)] Development of Drug Resistant Bacteria [see Warnings and Precautions (5.15)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

The NHANES protocols were authorized by the ethics board of National Centre for Health Statistics (NCHC), and written informed consent was obtained from all adult individuals

The value of the UK e-cigarette industry, 2018-29 Source: Statista | *Projected figures The UK vaping market saw consecutive rises between 7% and 8% in 2022 and 2023, with growth projected to drop below 4% in 2024

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