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For sulfonylureas, dose reduction or discontinuation should be strongly considered before initiating tirzepatide, as these medications provide diminishing benefit when combined with more effective agents and substantially increase hypoglycemia risk

Patients with OH usually undergo neurologic, cardiologic, and endocrine evaluation, because there are several causes for this presentation

Although enhanced glycolysis may transiently support cellular energy demands, it is markedly less efficient in ATP generation and is accompanied by lactate accumulation, increased production of reactive oxygen species (ROS), and activation of multiple metabolic bypass pathways

Topical application of SKQ1 eye drops 23 times per day for 46 weeks has been shown to increase tear film stability, reduce corneal fluorescein staining, and alleviate DE symptoms such as dryness, burning, foreign body sensation, and blurred vision [17, 174]