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Increasing evidence suggests that gut microbiota modulation plays a significant role in cancer immunotherapy

10.1016/j.jacc.2010.09.052 9 ChenZ.AnX.LiuX.QiJ.DingD.ZhaoM.et al (2017)

On the other hand, with the growing use of antitumor drugs, the prevalence of serious adverse iatrogenic effects caused by antitumor drugs have become a significant clinical issue in the cancer patient population [14]