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This exceptional capability is mainly attributable to the favorable gradient for fatty acids to cross the blood-brain barrier, either passively or via fatty acid binding proteins (FATPs), since once in the brain, unesterified fatty acids are converted to CoA thioesters by the long-chain-fatty-acid-CoA synthase (ACSL) family of proteins, therefore maintaining a continuous concentration gradient (see (Bazinet and Lay, Table 3 Fatty acid composition of total lipids in the hippocampus of 6 months old WT and APP/PS1 mice, and fed for 3 months with either Low-DHA or High-DHA diets