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Several excellent reviews have elaborately described the intricate relationship between macrophage polarization and metabolism [11, 13, 14, 16]

It plays a central role in: Detoxifying toxins and heavy metals Supporting immune health and inflammation balance Regenerating other antioxidants (like vitamins C and E) Maintaining mitochondrial energy production Slowing the cellular aging process A low Glutathione Index may reflect oxidative stress or a depletion of antioxidant capacity

In DW, the inflammatory response is abnormally prolonged, with excessive M1 macrophage polarization and sustained high expression of inflammatory cytokines (Deng et al., 2023

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