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Despite these revolutionary advances, significant challenges persisted in clinical practice, particularly within the tumor immunosuppressive microenvironment (TME), where the efficacy of immunotherapy was often severely compromised

The control of capillary and blood vessel growth is an important goal in order to promote increased blood flow to ischemic areas (growth), or to cut-off the blood supply (angiogenesis inhibition) of tumors

No significant differences were observed in the remaining parameters, including spare respiratory capacity, maximal respiration and coupling efficiency (Fig