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Description

Cytotoxicity profiling in vitro shows a dose-dependent pattern: cell viability holds within research-relevant concentration ranges but declines meaningfully above approximately 1 mM in culture, a threshold well outside the concentration windows described as biologically productive in the wound healing and gene expression literature

Ferroptosis has emerged as a significant player in cell death resulting from radiation therapy and has been extensively studied in cancerous, intestinal, hematopoietic, pulmonary, dermal, cardiovascular, ovarian, and neural tissue [8]