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Benjamin Rush was one of the first to point this out, in 1798, calling smoking "offensive" and a-moral, while also suggesting, correctly, that it can prompt "incurable diseases" and cancers

Born Moses Harry Horwitz, Howard outlived the other Stooges but died of lung cancer in 1975 at the age of 78

Vincent van Gogh, Public domain, via Wikimedia Commons Because he was in ill health at the time of making the painting, many consider it to be a memento mori painting, which is created to remind one of ones own imminent death