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It may manifest itself as itching, eczema, urticaria, reddening of the skin, or even localized skin lesions which may progress to destruction of the skin cells (necrosis), swelling (angioedema), or allergic shock (intense generalized malaise)

Clinical trials did not include pregnant or breastfeeding women, children, elderly individuals over 65, or those with active malignancy or severe organ dysfunction

It is essential for the production of red blood cells, the synthesis of DNA, and the metabolism of energy in addition to its role in nerve function

These patients can consider using Thermage every three to five years to try to put off a more invasive procedure