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We would like to acknowledge Dr

The raw sequence data reported in this paper have been deposited in the Genome Sequence Archive (Genomics, Proteomics & Bioinformatics 2021) in National Genomics Data Center (Nucleic Acids Res 2021), China National Center for Bioinformation/Beijing Institute of Genomics, Chinese Academy of Sciences (GSA: HRA003557) that are publicly accessible at We detected a significant decrease of spermidine and its related metabolites in the metabolomics data sets, including spermine and glutathione, in AA samples ( Figure 2 )

The adequate precision of the model, which assesses signal to noise ratio, was 14.63, with a ratio greater than 4 is desirable and after excluding the non-significant factors (Table 5), the best mathematical model explaining the behavior of the process can be reduced to that presented in Eq

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